Platelet Function
Platelets in
Hemostasis
| Morphology | Adhesion &
Aggregation
| Activation | Interactions
 
 

Platelets are 2.5 µm in average normal diameter and have a discod shape. The resting platelet is divided into three zones:

  • Peripheral zone: responsible for adhesion and aggregation. Consists of fluffy glycocalyx coat, cytoskeleton and platelet membrane. Contains absorbed coagulation factors I, V, VIII, XI, XII, receptors for ADP, thrombin, vWF, collagen, fibrinogen, fibrin, fibronectin, epinephrine, PAF, thrombospondin, thromboxane A2, prostacyclin, epinephrine, serotonin and glycosyl transferase.
  • Sol-Gel zone: responsible for contraction and support microtubule system. Contains the connecting system called the open canalicular system and the dense tubular system.
  • Organelle zone: contains the dense body system, non-metabolic ADP, serotonin, catecholamines, calcium, alpha granules; platelet factor 4, platelet mitogenic factor, fibrinogen, beta thromboglobulin, lysosomal granules, mitochondria and glycogen granules.

The following animation shows more information on platelet ultrastructure:

(Requires Adobe Flash Player™. Click here for free download). (For animation uses, please see Use of Content at Legal Information).

 
Cross-section of a resting platelet Cross-section of an activated platelet
 

Electron micrographs from a resting platelet (left, x10,000), or from an activated platelet showing pseudopodia emission (right, x5,000). Click on pictures to enlarge.
(Pictures have been kindly provided by Dr. J. White. For image uses, please see Use of Content at Legal Information).

See bibliografy

Last update: May 24, 2015


 
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Platelet Research Laboratory
Hospital Clínic - IDIBAPS
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